50 Cent was among those he was baffled by The Game's comments about Kanye West doing more for Game's career than Dr. Dre.

"Hun, what happen here," he Twitter captioned an article about The Game dismissing Dre and elevating Ye.

Of course, The Game and 50 Cent's issues run very deep and The Game responded to Fif's remark even the 50 already deleted the Tweet.

@50cent Last time you did this with me, G-Unit clothing got put in a casket wit the entire group & you went into television. I like Power n shit….. leave it alone. I’m back outside !!! #Numinati 🥷🏿

— The Goat (@thegame) March 4, 2022

"Last time you did this with me, G-Unit clothing got put in a casket wit the entire group & you went into television. I like Power n shit….. leave it alone. I’m back outside !!! #Numinati," Game typed.

This isn't the first time Game has taken credit for killing G-Unit clothing.  Here's what the former G-Unit soldier said in 2009, amid G-Unit clothing going out of business and 50 Cent's Before I Self Destruct album suffering relatively weak sales.

“It’s just Hip-Hop and I think that he’s more bitter towards me then anyone else he’s had drama with because look what I did to his brand. I killed G Unit,” Game told Complex.com. “I killed the clothes, I killed the brand, I killed Tony Yayo, Banks, and Buck at that time. Like I really f**ked up a lot of money for that dude. Not only for him but my label, Jimmy Iovine, who at this point, I’m apologetic to.”