Master P and his family have suffered a horrible tragedy.

His daughter Tytyana Miller has died at age 29.

Master P announced the death and the probable cause of death on Instagram.

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A post shared by Master P (@masterp)

Our family is dealing with an overwhelming grief for the loss of my daughter Tytyana. We respectfully request some privacy so that our family can grieve. We appreciate all of the prayers love and support. Mental illness & substance abuse is a real issue that we can’t be afraid to talk about. With God, we will get through this. #MyAngel."

Tytyana's brother Romeo Miller echoed his dad's words.

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A post shared by Romeo Miller (@romeomiller)

Tytyana and the Miller family had addressed her drug problems on their reality show Growing Up Hip Hop.

RIP, Tytyana.