Method Man was a guest on Kevin Hart's Gold Minds podcast and talked about dealing with depression as a young person.

“I was my own shadow, meaning I was in my own way,” said Meth, according to AllHipHop. “I had to get out of my own way. I saw that I could not control the people around me, but I could control myself. One thing that stood out for me, when I was younger – basically being a little dirty kid with nothing, no control over where I lived, what I ate, where I slept. But I had these sports, football and lacrosse, there I had control and I was good at it.”
 
“So I needed those little moments where I need to be in control of what goes on in my life," he added. "I had to look myself in the mirror and say, ‘I’m tired of myself. I want better for me, I have more to contribute,' and start there. Self-check, absolutely. If you don’t, sooner or later, somebody else is gonna check you.”

Other rappers who've opened up about their depression include Meek Mill, Lizzo, and Big Sean. 

But 50 Cent once said that depression is a "luxury," which he got a lot of pushback over.